Overview
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
5.5
USERS' SCORE
Moderately Good
Based on 3 Reviews
7.7
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
5-HTP (5-hydroxytryptophan) (from Griffonia simplicifolia Extract) (seed)
50 mg
*
Top Medical Research Studies
7
In our investigation, we examined the impact of 5-hydroxytryptophan (5-HTP) on individuals with irritable bowel syndrome (IBS) compared to healthy volunteers.
Using a randomized double-blind placebo-controlled approach, we found that while 5-HTP led to increased pain perception in hypersensitive IBS patients, it also caused similar effects in some healthy controls.
Notably, IBS patients showed significant changes in serotonin metabolites alongside altered pain thresholds. However, these changes weren't beneficial across the board, as non-hypersensitive IBS patients did not experience the same response.
Using a randomized double-blind placebo-controlled approach, we found that while 5-HTP led to increased pain perception in hypersensitive IBS patients, it also caused similar effects in some healthy controls.
Notably, IBS patients showed significant changes in serotonin metabolites alongside altered pain thresholds. However, these changes weren't beneficial across the board, as non-hypersensitive IBS patients did not experience the same response.
Read More
4
We assessed the impact of 5-hydroxytryptophan (5-HTP) on intestinal health in patients with irritable bowel syndrome (IBS) and healthy individuals. In a randomised double-blind placebo-controlled study, we found that while 5-HTP improved mucosal serotonin levels and reinforced intestinal barriers in healthy participants, the same benefits were absent in IBS patients. This suggests IBS may involve a dysfunctional serotonin system, hindering the ability to strengthen the intestinal barrier even after 5-HTP treatment. Overall, our findings indicate limited effectiveness for 5-HTP in treating IBS.
Read More
Most Useful Reviews
7.5
Noticed calming effects
1 people found this helpful
I sought a supplement to stabilize my mood and combat stress, choosing 5-HTP from a reputable brand. The initial days brought no significant results, apart from improved sleep, but after a week, I noticed I became less irritable, with negative thoughts dissipating quicker. I used to react explosively to minor annoyances, but now I feel a pause that allows me to choose my response better. I experienced no side effects and can recommend it, as it shows effectiveness for me.
Read More
7.5
Enhanced sleep quality
After eating, I find that the quality of my sleep improves. I feel less anxious and irritable the following day. I am uncertain if this is a psychological effect.
Read More
0
Negative side effects
Unfortunately, it had an adverse effect on me, leading me to stop taking it. While I do not deem it a bad product, 5-HTP is not suitable for everyone and can cause side effects. It was particularly hard for me to wake up, and I was very irritable in the morning after taking it.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
5.5
- All Researches
7
In our investigation, we examined the impact of 5-hydroxytryptophan (5-HTP) on individuals with irritable bowel syndrome (IBS) compared to healthy volunteers.
Using a randomized double-blind placebo-controlled approach, we found that while 5-HTP led to increased pain perception in hypersensitive IBS patients, it also caused similar effects in some healthy controls.
Notably, IBS patients showed significant changes in serotonin metabolites alongside altered pain thresholds. However, these changes weren't beneficial across the board, as non-hypersensitive IBS patients did not experience the same response.
Using a randomized double-blind placebo-controlled approach, we found that while 5-HTP led to increased pain perception in hypersensitive IBS patients, it also caused similar effects in some healthy controls.
Notably, IBS patients showed significant changes in serotonin metabolites alongside altered pain thresholds. However, these changes weren't beneficial across the board, as non-hypersensitive IBS patients did not experience the same response.
Read More
4
We assessed the impact of 5-hydroxytryptophan (5-HTP) on intestinal health in patients with irritable bowel syndrome (IBS) and healthy individuals. In a randomised double-blind placebo-controlled study, we found that while 5-HTP improved mucosal serotonin levels and reinforced intestinal barriers in healthy participants, the same benefits were absent in IBS patients. This suggests IBS may involve a dysfunctional serotonin system, hindering the ability to strengthen the intestinal barrier even after 5-HTP treatment. Overall, our findings indicate limited effectiveness for 5-HTP in treating IBS.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 3 Reviews
7.7
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Noticed calming effects
1 people found this helpful
I sought a supplement to stabilize my mood and combat stress, choosing 5-HTP from a reputable brand. The initial days brought no significant results, apart from improved sleep, but after a week, I noticed I became less irritable, with negative thoughts dissipating quicker. I used to react explosively to minor annoyances, but now I feel a pause that allows me to choose my response better. I experienced no side effects and can recommend it, as it shows effectiveness for me.
Read More
7.5
Enhanced sleep quality
After eating, I find that the quality of my sleep improves. I feel less anxious and irritable the following day. I am uncertain if this is a psychological effect.
Read More
0
Negative side effects
Unfortunately, it had an adverse effect on me, leading me to stop taking it. While I do not deem it a bad product, 5-HTP is not suitable for everyone and can cause side effects. It was particularly hard for me to wake up, and I was very irritable in the morning after taking it.
Read More
Frequently Asked Questions
7.5
Noticed calming effects
1 people found this helpful
I sought a supplement to stabilize my mood and combat stress, choosing 5-HTP from a reputable brand. The initial days brought no significant results, apart from improved sleep, but after a week, I noticed I became less irritable, with negative thoughts dissipating quicker. I used to react explosively to minor annoyances, but now I feel a pause that allows me to choose my response better. I experienced no side effects and can recommend it, as it shows effectiveness for me.
0
Negative side effects
Unfortunately, it had an adverse effect on me, leading me to stop taking it. While I do not deem it a bad product, 5-HTP is not suitable for everyone and can cause side effects. It was particularly hard for me to wake up, and I was very irritable in the morning after taking it.
7.5
Enhanced sleep quality
After eating, I find that the quality of my sleep improves. I feel less anxious and irritable the following day. I am uncertain if this is a psychological effect.
4
We assessed the impact of 5-hydroxytryptophan (5-HTP) on intestinal health in patients with irritable bowel syndrome (IBS) and healthy individuals. In a randomised double-blind placebo-controlled study, we found that while 5-HTP improved mucosal serotonin levels and reinforced intestinal barriers in healthy participants, the same benefits were absent in IBS patients. This suggests IBS may involve a dysfunctional serotonin system, hindering the ability to strengthen the intestinal barrier even after 5-HTP treatment. Overall, our findings indicate limited effectiveness for 5-HTP in treating IBS.
7
In our investigation, we examined the impact of 5-hydroxytryptophan (5-HTP) on individuals with irritable bowel syndrome (IBS) compared to healthy volunteers.
Using a randomized double-blind placebo-controlled approach, we found that while 5-HTP led to increased pain perception in hypersensitive IBS patients, it also caused similar effects in some healthy controls.
Notably, IBS patients showed significant changes in serotonin metabolites alongside altered pain thresholds. However, these changes weren't beneficial across the board, as non-hypersensitive IBS patients did not experience the same response.
Using a randomized double-blind placebo-controlled approach, we found that while 5-HTP led to increased pain perception in hypersensitive IBS patients, it also caused similar effects in some healthy controls.
Notably, IBS patients showed significant changes in serotonin metabolites alongside altered pain thresholds. However, these changes weren't beneficial across the board, as non-hypersensitive IBS patients did not experience the same response.
References
- Keszthelyi D, Troost FJ, Jonkers DM, van Eijk HM, Dekker J, et al. Visceral hypersensitivity in irritable bowel syndrome: evidence for involvement of serotonin metabolism--a preliminary study. Neurogastroenterol Motil. 2015;27:1127. 10.1111/nmo.12600
- Keszthelyi D, Troost FJ, Jonkers DM, van Eijk HM, Lindsey PJ, et al. Serotonergic reinforcement of intestinal barrier function is impaired in irritable bowel syndrome. Aliment Pharmacol Ther. 2014;40:392. 10.1111/apt.12842
